CÂNCER DE BOCA: EXPRESSÃO IMUNO-HISTOQUÍMICA DE c-erbB-2, Bcl-2 E EGFR - ESTUDO COMPARATIVO COM LEUCOPLASIA E HIPERPLASIA INFLAMATÓRIA ORAL CANCER: IMMUNOHISTOCHEMICAL EXPRESSION OF c-erbB-2, Bcl-2 AND EGFR - STUDY WITH LEUKOPLAKIA AND INFLAMMATORY HYPERPLASIA

SUMMARY Abnormalities in genes that regulate the proliferation and cell death can provoke many lesions as oral epidermal carcinoma. It has been related that genetic alterations in tumoral cells predict the biologic agressivity in the tumors. Genetic markers as cerbB-2, Bcl-2 and EGFR are considered indicators of prognostic to the pre-malignant lesions and neoplasias. Objective: to study in the fragments of incisional biopsy the expression of c-erbB-2, Bcl-2 and EGFR proteins. Materials and methods: 54 cases of epidermal carcinoma, 25 cases of neoplasias and 26 cases of hyperplasias obtained from Oral Pathology’s Laboratory of Federal University of Mato Grosso do Sul (UFMS). The used method was streptoavidin-biotinperoxidase in Patthology’s Laboratory of University Brasilia (UNB). Results: The results revealed positivity significant of EGFR proteins to the oral epidermal carcinoma and to the other one protein there was no statistical significant difference. Conclusions: The results suggest that EGFR can be used as a marking in oral epidermal carcinoma and can contribute to the progression of neoplasia, however, being insufficient to predict the carcinogenesis. UNITERMS: factors of prognostic; immunohistochemical, epidermal carcinoma.