WS03.6 Pregnancies after lung transplantation: A retrospective multicenter French study about 39 pregnancies

Objectives Pregnancy after lung transplantation remains rare. This French study deals with maternal and newborn outcomes and change in lung function after a pregnancy. Methods We retrospectively included 39 pregnancies in 35 lung transplant recipients over more than 20 years. Data about patients, course of pregnancies and newborns were collected from nine of the eleven French transplantation centers. Results Mean age at time of pregnancy was 28±5years. Cystic fibrosis affected 71% of our patients. Mean time between transplantation and pregnancy was 63±44 months. Twenty six births occurred (67%) with a mean term of 36±5 weeks gestation and a mean birth weight of 2409±921 g. Prematurity was observed in 11 cases (43%). Forced expiratory volume in one second was measured at 83.9% pred. before pregnancy and at 77.3% pred. 12 months later (p = 0.04). Ten patients developed chronic lung allograft dysfunction, 22.5±14.6 months after delivery. Up to now, nine patients died with a mean time after transplantation of 8.2±7 years and a mean time after pregnancy of 4.6±6.5 years. Conclusion Pregnancy in lung transplant recipients is possible. Maternal and newborn complications are more frequent than in general population. Survival in this cohort appears to be similar to global survival observed in lung transplant recipients. Planned pregnancy and multidisciplinary follow-up are crucial.