Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

ObjectiveThe goal of this study was to determine the effect of a genetic variant in the organic cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S, on the pharmacokinetics of the antidiabetic drug, metformin.MethodsThe uptake of metformin was performed in stably t