Effects of Huoxue yihao Capsules on Carotid Intima-media Thickness and Vascular Endothelial Function of Patients with Grade-2 Hypertension

OBJECTIVE: To evaluate the effects of Huoxue yihao capsules on carotid arterial intima-media thickness(CIMT) and vascular endothelial function of patients with grade-2 hypertension.METHODS: 102 patients with grade-2 hypertension were randomly assigned to receive Levamlodipine besylate tablet alone (control group) or Levamlodipine besylate tablet plus huoxue yihao capsules(trial group) for 24 weeks.The CIMT and the reactive internal diameter of brachial artery were measured before and after treatment.RESULTS: Before treatment,in grade-2 hypertensive patients compared with healthy adults,the levels of CIMT increased markedly(P0.05) and the levels of the reactive internal diameter of brachial artery decreased markedly(P0.05).After treatment,the levels of CIMT in both groups decreased as compared with before treatment(P0.05),much as in Huoxueyihao group;moreover,the levels of reactive internal diameter of brachial artery in both groups increased after treatment(P0.05),much as in Huoxue yihao group.CONCLUSION:Huoxue yihao capsule can delay the progression of atherosclerosis and improve endothelial function in patients with grade-2 hypertension.