Pharmacogenomics and pharmacoepigenomics: Impact on therapeutic strategies

Abstract Pharmacoepigenomics aims to investigate the effects of epigenetic alterations exert on the drug response (safety and efficacy). The genes that play a role in pharmacogenomics also get modulated by epigenetic amendments that further tunes the therapeutic outcome. Today, due to technological advancements, pharmacogenomics and pharmacoepigenetic can assist in addressing the ambitious queries related to interindividual variations in drug response. It enhances the opportunity to improve the treatment outcome as well as patient compliance. Hence, the inclusion of pharmacogenomics and pharmacoepigenetic explorations have been univocally advocated as routine procedures for the proper evaluation of drug efficacy and toxicity concerns as a part of drug development as well as clinical studies. This chapter discusses the pharmacogenomics and pharmacoepigenomics and its impact on therapeutic strategies.