Formulation and Characterization of Ibuprofen Sustained Release Tablets by Solid Dispersion Technique

The objective of the present study was developed as sustained release tablets of Ibuprofen by solid dispersion technique. The results of FTIR study and DSC study confirmed that there is no chemical interaction or no incompatibility between the drug and excipients. The solid dispersion technique would be an effective approach for increasing the solubility and increasing dissolution behaviour of poorly water soluble drug. The granules were evaluated for precompression parameters like Bulk density, Tapped density, Angle of repose, Carr’s index, Hausner’s ratio. Ten formulations were fabricated using with suitable rate controlling polymers like HPMCK4MCR, HPMCK100MCR. The compressed tablets were evaluated for post compressive parameters like Weight variation, Friability, Hardness, Drug content, was within the Pharmacopoeial limit. The in vitro dissolution study was performed for various formulations and marketed formulation. Based on the results F7IB was shown highest drug release 99.41% within 24hrs. Various formulations were subjected to various model dependent kinetics like Zero order, First order, Higuchi, Korsmeyer-peppas release kinetics. The release profile exhibiting maximum r2 value was found to obey that Fickian diffusion kinetics. It was observed F7IB was found to be Zero order release kinetics. Stability study was conducted as per ICH guidelines and the results showed that there is no physical or chemical change. It may be concluded that the sustained release tablets of Ibuprofen by solid dispersion technique may reduce the dosing frequency and improve the patient compliance.