Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

Ralf Buettner,Corey Morales,Enrico Caserta,Estelle Troadec,Emine Gulsen Gunes,Domenico Viola,Jihane Khalife,Hongzhi Li,Jonathan J. Keats,Austin Christofferson,Xiwei Wu,Timothy W. Synold,Joycelynne Palmer,James F. Sanchez,Alexander Pozhitkov,Nagarajan Vaidehi,Guido Marcucci,Amrita Krishnan,Michael Rosenzweig,Flavia Pichiorri,Steven T. Rosen

Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

2019

Key Points Teriflunomide, the active metabolite of leflunomide, downregulates c-Myc expression through inhibition of PIM kinases. Leflunomide together with lenalidomide significantly extended survival in an in vivo MM model.

Keywords:

Lenalidomide
Cancer research
Pim kinases
Active metabolite
Leflunomide
Teriflunomide
In vivo
Chemistry
C-myc Genes

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