Competing Risks to Transplant in Bridging with Continuous Flow Left Ventricular Assist Devices
2021
Abstract Background Continuous flow left ventricular assist device(CF-LVAD) support is a mainstay in the hemodynamic management of patients with end-stage heart failure refractory to optimal medical therapy. In this report, we evaluated waitlist complications and competing outcomes for CF-LVAD patients compared to primary transplant candidates listed for orthotopic heart transplantation(OHT) at a single center. Methods All patients listed for OHT between 2006-2020 at our institution were retrospectively reviewed(n=300 CF-LVAD; n=244 primary transplant). Kaplan-Meier methodology with log-rank testing was used to evaluate survival outcomes. Terminal outcomes of death, delisting, and transplant were assessed as competing risks and compared between groups using Gray’s test. Multivariable Fine-Gray regression was used to identify predictors of transplantation. Results One-year rates of transplant, delisting, and death were 48%, 8%, and 2%, respectively for CF-LVAD patients and 45%, 15%, and 9% for primary transplant(all P Conclusions While device related-complications were significantly associated with decreased rates of transplant, CF-LVAD patients had excellent waitlist outcomes overall. In light of the 2018 allocation score change, the risk of complications should be taken into account when deciding whether to offer CF-LVAD as a bridge to transplant.
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