Activity of ciprofloxacin (BAYo 9867) against Pseudomonas aeruginosa and ampicillin-resistant enterobacteriaceae

We studied thein vitro activity of ciprofloxacin against 570 strains of ampicillin-resistantEnterobacteriaceae and 286Pseudomonas aeruginosa strains. 95.26% of theEnterobacteriaceae and 53.45% of theP. aeruginosa were inhibited by 0.1 mg/l of ciprofloxacin. 2 mg/l of ciprofloxacin inhibited all of theEnterobacteriaceae strains and 4 mg/l all of theP. aeruginosa. We compared the activity of ciprofloxacin with that of temocillin in theEnterobacteriaceae strains. In theP. aeruginosa strains, classified according to their susceptibility to carbenicillin and gentamicin, we compared the activity of ciprofloxacin with that of ceftazidime. In the strains studied, thein vitro activity of ciprofloxacin is superior to that of temocillin against theEnterobacteriaceae and to that of ceftazidime against theP. aeruginosa strains.