A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.

Gudrun Göhring,Kathrin Thomay,Gunnar Schmidt,Tim Ripperger,Michael Xu,Nicole Wittner,Mwe Mwe Chao,Irith Baumann,Marena Niewisch,Dirk Reinhardt,Thomas Klingebiel,Felicitas Thol,Brigitte Schlegelberger,Charlotte M. Niemeyer

A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl.

2017

Gudrun Göhring
Kathrin Thomay
Gunnar Schmidt
Tim Ripperger
Michael Xu
Nicole Wittner
Mwe Mwe Chao
Irith Baumann
Marena Niewisch
Dirk Reinhardt
Thomas Klingebiel
Felicitas Thol
Brigitte Schlegelberger
Charlotte M. Niemeyer

The gene encoding for DNA methyltransferase 3A (DNMT3A) is one of the most frequently mutated genes in hematologic malignancies. In myeloid neoplasia, DNMT3A mutations are most prevalent in acute m...

Keywords:

Bone marrow
clone (Java method)
Somatic evolution in cancer
DNA methylation
Immunology
Myelodysplastic syndromes
Genetics
Allele
DNA Mutational Analysis
Mutation
Medicine
Girl

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