Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.

Liangqin Guo,Zhixiong Ye,Feroze Ujjainwalla,Heather L. Sings,Iyassu K. Sebhat,John Huber,David H. Weinberg,Rui Tang,Tanya MacNeil,Constantin Tamvakopoulos,Qianping Peng,Euan MacIntyre,Lex H.T. Van der Ploeg,Mark T. Goulet,Matthew J. Wyvratt,Ravi P. Nargund

Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.

2008

Liangqin Guo
Zhixiong Ye
Feroze Ujjainwalla
Heather L. Sings
Iyassu K. Sebhat
John Huber
David H. Weinberg
Rui Tang
Tanya MacNeil
Constantin Tamvakopoulos
Qianping Peng
Euan MacIntyre
Lex H.T. Van der Ploeg
Mark T. Goulet
Matthew J. Wyvratt
Ravi P. Nargund

Discovery of a series of tert-butyl pyrrolidine derived, potent and orally bioavailable melanocortin receptor subtype-4 (MC4R) selective modulators is disclosed.

Keywords:

Melanocortin receptor
Melanocortin
Agonist
G protein-coupled receptor
Bioavailability
Receptor
Pyrrolidine
Chemistry
Biochemistry
Chemical synthesis
Oral administration

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