Acidic triazoles as soluble guanylate cyclase stimulators

Lee R. Roberts,Paul Anthony Bradley,Mark E. Bunnage,Katherine S. England,David Fairman,Yvette M. Fobian,David Nathan Abraham Fox,Geoff E. Gymer,Steven E. Heasley,Jerome Molette,Graham L. Smith,Michelle Schmidt,Michael A. Tones,Kevin Neil Dack

Acidic triazoles as soluble guanylate cyclase stimulators

2011

Lee R. Roberts
Paul Anthony Bradley
Mark E. Bunnage
Katherine S. England
David Fairman
Yvette M. Fobian
David Nathan Abraham Fox
Geoff E. Gymer
Steven E. Heasley
Jerome Molette
Graham L. Smith
Michelle Schmidt
Michael A. Tones
Kevin Neil Dack

Abstract A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF 3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25 .

Keywords:

GUCY1B3
Triazole
Guanylate Cyclase Stimulators
Molecule
Enzyme
GUCY1A3
Organic chemistry
Biochemistry
Chemistry

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