Analysis of drug therapy of 53 patients with Corona Virus Disease-2019

Objective:To explore safe and effective treatment strategies for the patients with Corona Virus Disease-2019 (COVID-19). Methods: The clinical data and treatment strategies of COVID-19 patients were collected and retrospectively analyzed. Results: Major clinical manifestations of the patients with COVID-19 were fever (75. 5%) and cough (41. 5%). Of the 53 COVID-19 patients, 42 were of common type, 6 were of severe type and 5 were of critical type. Most of the critical type patients were the elderly with basic diseases. Serum lymphocyte count decreased when they were admitted into hospital. During hospitalization,C-reactive protein significantly increased in critical type patients. Liver injury was observed in severe type and critical type patients. With regard to treatment, 30 patients in the common type were treated with traditional Chinese medicine alone, 8 patients were treated with traditional Chinese medicine combined with lopinavir/ritonavir(LPV/r), 2 patients were given traditional Chinese medicine combined with other drugs, and still another 2 patients were given interferon alone. One severe type patient was treated with LPV/r combined with glucocorticoids, traditional Chinese medicine was given to other 5 severe type patients, including 2 patients with methylprednisolone sodium succinate combined treatment and one patient with interferon combined treatment. The treatment of the critically ill patients was relatively complex, including antiviral, diuretic, cardiotonic treatment, as well as nutritional support. Conclusion;Traditional Chinese medicine was beneficial to the recovery of COVID-19 patients. However, definite benefits of combined treatment with LPV/r or glucocorticoids were not clearly observed. © 2020 Publishing House of Pharmaceutical Care and Research. All rights reserved.