Correlation Study on Neck Lymph Node Metastasis and α-Catenin,β-Catenin Expression in Oral Squamous Cell Carcinoma Tissue

Correlation between neck lymph node metastasis (NLNM) and αcatenin,βcatenin expression in oral squamous cell carcinoma (OSCC) was studied through samples from 68 cases by protein hybridization adopting Western blotting to detect the expression level of αcatenin and βcatenin. As compared with OSCC without NLNM (32 cases), the expression level of αcatenin and βcatenin in OSCC with NLNM (36 cases) lowered apparently (P0.01). These results suggested that there is close correlation between NLNM of OSCC and the loss of αcatenin and βcatenin expression. And it can be valuable in determination of the development possibility of the tumor metastasis and judging indices after recover.;