Состояние свободнорадикальных процессов в ткани злокачественной опухоли толстой кишки

The purpose of the study. An examination of some indicators of the systems POL-AO in cancer tissue of rectum and sigmoid. Materials and Methods. In samples of tumor tissue, perifocal zone and resection line obtained from 73 patients (43 women and 30 men) with primary adenocarcinoma (st III) of sigmoid and rectal parts of large intestine by enzyme immunoassay studied the levels of malondialdehyde (MDA), glutathione peroxidase (GAP) and superoxide dismutase (SOD), catalase activity, the content of diene conjugates (DC), vitamins E and A. Results. In tumor tissues was detected repression of free radical oxidation, expressed in reducing the amount of primary and secondary products of lipid peroxidation and antioxidant enzymes opposite changes in the protection of rectum and sigmoid colon. In perifocal zone tumors of various parts of the colon, with the violation ratio LPO antioxidants, reflecting changes in some indicators in the most malignant tumors, i.e on the flow of free radical processes it occupies an intermediate position between the tumor tissue and the colon by resection line. Conclusion. These results confirm the pathogenetic significance of changes in the activity of free radical oxidation for the growth and development of malignancies.