Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[ 18 F]Fluoro- d -Glucose Uptake in Prostate Cancer Mouse Xenografts

Purpose Prostate cancer (PCa) is the second most common cause of cancer-related death among men in the United States. Due to the lipid-driven metabolic phenotype of PCa, imaging with 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) is suboptimal, since tumors tend to have low avidity for glucose.