Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive Immunity
2019
Purpose of Review
Immunotherapy has emerged as a promising cancer treatment; however, success in only select clinical indications underscores the need for novel approaches. Recently Listeria monocytogenes–based vaccines have been developed to drive tumor-specific T cell responses. Here, we discuss recent preclinical studies using L. monocytogenes vaccines, innate immune pathways that influence T cell priming, and new vaccine strategies in clinical trials.
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