EVIDENCE OF ANTI-DOUBLE STRANDED DNA ANTIBODIES AND C-REACTIVE PROTEIN IN EGYPTIAN PATIENTS WITH HIGH ANTI-SCHISTOSOMA MANSONI ANTIBODY TITER

Schistosomiasis is one of the major public health diseases that induced a diversity of immunologicreactions. Significant association between autoreactive antibodies and autoimmune disorderswas suggested. This study investigated the presence of anti-double stranded DNA (anti-dsDNA) antibodies and inflammatory biomarker, C-reactive protein (CRP) in 89 Egyptian patients,with Schistosoma mansoni clinical evidence and high anti-Schistosoma antibody titer. Theresults showed positive serum anti-ds DNA antibodies in 11/89(12.4%) of them, without significanceto age, sex or anti-Schistosoma antibody titers. CRP was positive in 20/89(22.5%) of patients,with significant correlation with anti-ds DNA antibodies (P=0.000).