Impact of Residual Subretinal Fluid Volumes on Treatment Outcomes in a SRF-tolerant Treat & Extend Regimen

PURPOSE: To investigate associations between residual subretinal fluid (rSRF) volumes, quantified using artificial intelligence (AI) and treatment outcomes in a SRF-tolerant treat-and-extend (TE p=0.014) and 6mm (-0.024 letters/nl; p=0.049). A negative association between increased interval and BCVA change was found for rSRF in 1 and 6mm (-0.250 and -0.233 letter/week interval, respectively, both p<0.001). Extended intervals despite rSRF had significantly higher SRF-volumes in the central 6mm at the following visit (p=0.002). CONCLUSION: AI-based analysis of extended visits despite rSRF demonstrated increasing SRF-volumes associated with BCVA loss at the consecutive visit. This negative association contributes to our understanding of rSRF volumes on treatment outcomes in nAMD.