Abstract TP433: Free Leptin And Soluble Leptin Receptor: Novel Circulating Markers Of Carotid Plaque - Related Symptomatology And Potential Role In Plaque Stability (from The Opal-lille Carotid Endarterectomy Study)

Leptin, an adipocyte-derived cytokine with various effects on the cardiovascular system, circulates in a free biologically active form and a bound form to a soluble leptin receptor (sObR) involved in modulating leptin activity. The links between free leptin, sObR, human atherosclerotic carotid plaque phenotype remain unknown. In the present study, we investigated the potential links between serum/plaque free leptin, serum sObR, carotid plaque stability and related symptomatology in 146 consecutive patients (71 asymptomatic and 75 symptomatic) scheduled for carotid endarterectomy. Free leptin was assessed in serum (17.05±23.19 ng/mL, range 0.47-191) and carotid plaques (0.204±0.486 ng/mg protein) and sObR in serum (21.48±8.81 ng/ml). Serum free leptin concentrations were correlated negatively with serum sObR concentrations and positively with intra-plaque free leptin concentrations (p<0.0001, r=0.491, p<0.0001, r=0.726, respectively). Serum free leptin and sObR concentrations were independently associated ...