Pharmaceutical compositions Oral controlled release of 5,8,14-triazatetracyclo (10.3.1.0 (2,11) .0 (4,9) -hexadeca-2 (11) 3,5,7,9-pentaene.

A dosage form suitable controlled release for oral administration to a subject comprising 5, 8, 14-triazatetra-cyclo [10.3.1.02, 11.04, 9] -hexadeca-2 (11), 3, 5, 7, 9- pentaene, or a pharmaceutically acceptable salt thereof, and a means for administering said compound or salt to said subject at a rate of less than about 6 mg / hour, whereby at least about 0 1 mg of the compound, or salt pharmaceutically acceptable thereof, it is administered over a period of 24 hours.