Formulasi sediaan antiseptik mulut dari katekin gambir

Gambir has been found to be effective against Staphylococcus mutans which associated with the prevention of plaque formation (Kozai, 1995). This paper reports formulation of catechin, a major component of gambir, as antiseptic gargled solution. Due to catechin’s poor solubility and stability, two dry dosage forms were made: effervescent granules (F1) and instant powder with separated solvent (F2). Evaluation of dosage forms showed that both dried formulas showed good powder properties. However, catechin in F1 turned brown in color which was associated with oxidation during granulation. There was a decrease in catechin concentration of F1 from (95.82 + 0.01 %) to (90.76 + 0.90 %) after 6 weeks of storage at room temperature. Reconstitution of F2 gave a golden yellow solution, the cathecin content decreased from (97.30 + 0.40 %) to (93.84 + 1.14 %) under similar conditions.