Enantioselective palladium catalyzed allylic substitutionwith sulfur-containing pyridine ligands

Diastereomerically pure (5R,7R,8S)- and (5R,7R,8R)-5,6,7,8-tetrahydro-6,6-dimethyl-2-phenyl-8-phenyltio-5,7-methanoquinoline were prepared and assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivities up to 83 % were obtained.