The clinical therapeuric effect of the intrathecal injection with vancomycin for intracranial infection: reports 25 cases

Objective To explore the clinical therapeuric effect of the intrathecal injection with vancomycin for intrcranial infection.Methods Twenty-five patients with intracranial infection were treated by 20.0 mg vancomycin diluted with 5.0 ml sodium chloride injection into lumber tube by its the external drainage once a day.The drainage tube had two hours occlusion after drug injection.When the temperature and white blood cell in cerebrospinal fluid of patients were normal the drainage tubes were removed.Results Twenty cases were cured, four cases had favourable outcome.One case was dead(4.0%).Conclusion The treatment of intrathecal injection with vancomycin for patient with intracranial infection could be satisfactory.