One-Pot Chemoselective Domino Condensation to Form Fused Pyrrolo-Pyrazino-Indolizines Framework: Discovery of Novel AIE Molecules
2020
Luminogens with AIE (aggregation-induced emission) properties have been rapidly developed and are widely applied in many fields, such as solar cell research, biosensor study and bio-imaging advancement. It remains highly desirable to acquire new AIE molecules with excellent luminescence characteristics through facile, rapid, and efficient synthesis. Here, a chemoselective domino condensation to form highly fused pyrrolo[1′,2′:1,6]pyrazino[2,3-g]indolizines (5-6-6-5) was developed using N-substituted pyrrole-2-carbaldehydes and pyrrole-2-carbonitriles. The resultant products showed good AIE properties, exhibiting strong yellow fluorescence at up to 571 nm with a large Stokes shift (170 nm). Further live cell imaging and biocompatibility studies suggested that these products may find potential applications in various biomedical fields.
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