Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum

Abstract An alkaloid with novel skeleton, sinoscrewtine ( 1 ), has been isolated from the roots of Sinomenium acutum . Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H 2 O 2 /Aβ 25–35 induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC 50 of 32.6 μM.