Динамика экскреции с мочой матриксных белков при пиелонефрите у детей

In children, infectious inflammatory diseases of organs of urinary system, pyelonephritis included, can result in renal tissue hardening as a result of excessive accumulation of components of extracellular matrix in interstitial tissue due to imbalance in the synthesis/proteins degradation system of extracellular matrix. The degradation of proteins occurs under impact of proteinases, in particular matrix metalloproteinases named as biological markers of fibrosis. The study covered the evaluation of content of metalloproteinases 2 and 9 and tissue inhibitor of matrix metalloproteinases 1 in urine of 135 children with pyelonephritis. The established disorders of balance between pro-inflammatory and antiinflammatory, pro-sclerotic compounds can testify the atypical course of inflammation with subsequent formation of sclerosis focuses. This is needed for assigning the treatment tactics and following-up of patients with pyelonephritis.