Gastrointestinal transit of non-disintegrating tablets in fed subjects

Abstract The gastrointestinal transit of non-disintegrating tablets of different sizes (3–7 mm diameter) was monitored in fed subjects. Transit of the tablets was followed using the technique of γ-scintigraphy. Neither the gastric emptying nor small intestine transit of the tablets was affected by their size. However, the nature of the meal consumed had a marked effect on gastric emptying. The nature of the meal also appeared to influence the transit through the ileocaecal sphincter.