Mutation process and malignant transformation induced by adenoviruses in mammalian cells

Both oncogenic adenovirus (BAV-3) and nononcogenic adenovirus (Ad-1) are able to induce gene mutations in cultured mammalian cells. In the case of equal multiplicity of the infection the frequency of induced mutations is higher in variants with Ad-1. Unlike Ad-1 both mutagenic and transforming effects of BAV-3 are intensified by means of TPA promoters. TPA modifies analogously mutagenic and transforming effect of much less than oncogenic fragment much greater than of DNA BAV-3. Oncogene and, probably, other viral genes reveal mutagenic activity.