A depsipeptide fungal metabolite inhibitor of cholesteryl ester transfer protein

Abstract The organic extract of the fermentation broth of a fungus was found to contain a depsipeptide SCH 58149 ( 1 ), containing three amino acids and a β-hydroxy acid, by spectroscopic studies. The amino acids were phenyl alanine, alanine and leucine and the β-hydroxy acid is 3-hydroxy-4-methyl octanoic acid. SCH 58149 exhibited weak activity against cholesterol ester transfer protein (CETP) with an IC 50 of 50 μM.