Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio
2013
The ratio between ATP and ADP within the cell is a key indicator of metabolic status. Tantama et al. describe a ratiometric, genetically encoded fluorescent sensor for ATP:ADP that is now optimized for mammalian cells, and demonstrate that it can detect physiological changes in energy consumption and production.
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