Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

C-terminal mutations in the XPB helicase subunit of TFIIH are associated with cancer. Here, using Drosophila models, the authors demonstrate C-terminally truncated Hay/XPB alleles enhance overgrowth dependent on Hfp, the orthologue of the MYC transcriptional repressor FIR.