Содержание аминокислот и нейромедиаторов в сыворотке крови детей с синдромом дефицита внимания / гиперактивности

Disbalance of amino acids, serotonin and catecholamines may be crucial in pathology of attention deficit hyperactivity disorder (ADHD). We measured concentrations of amino acids, serotonin, kynurenin and kynurenic acid in serum and catecholamines in plasma of children with ADHD. A decrease in norepinephrine and dopamine as well as in the excitatory to inhibitory amino acids ratio was observed that can result in disturbed ability to attention control, to decreased functional activity of brain and delay in its development. A decrease in serotonin may be associated with increased aggression and disturbed trophic function and plasticity of brain. Decreased taurin and increased kynurenin may indicate increased neurotoxicity in ADHD.