2-1,4-dihydropyridine-selenometil, a process for their preparation and pharmaceutical compositions containing them.

Compounds of formula (I) wherein R1 is cyano, nitro, acetyl, benzoyl or alkoxycarbonyl, R2 is an optionally substituted phenyl or hetaryl GROUP; R3 is an alkoxycarbonyl group; R4 is an alkyl group optionally substituted by hydroxy, amino, phenyl or heterocyclic group; A GROUP OR phenyl optionally substituted heterocyclic group. COMPOUNDS I are useful in human therapy as agents capable of interacting with CA ++ DEPENDENT SYSTEMS AS AGENTS AND ANTI-TUMOR.