Immunologic Aspects of Intracerebral CNS Tissue Transplantation

The development of intracerebral grafting (ICG) techniques intended to alleviate neurologic disorders has led to an increased interest in immune responses in the brain. In spite of the great advances made in the general understanding of such responses after transplantation of foreign tissues, a number of factors particularly important for immune responses within the central nervous system (CNS) still require elucidation. This chapter will review some of the mechanisms involved and describe some key findings on the immunologic constraints that are relevant for successful ICG.