생약제제의 이화학적 품질평가에 관한 연구 갈근탕의 분석

The prescription of Gal Gun Tang, which has been used for treatment of cold, fever, and muscular pain in Chinese herb medicine is produced in the form of decoction. However, the storage problem for this dosage form remains unsettled. Using HPLC and GC, we examined quantitative change of major constituents caused by time-progress and temperature-change. Nine major constituents, such as cinnamaldehyde, cinnamic acid, ephedrine, puerarin, paeoniflorin, daidzin, benzoic acid, glycyrrhizin and liquiritin were selected as references. The content of cinnamaldehyde significantly decreased by the increase of temperature while that of cinnamic acid increased. Benzoic acid showed the most significant change of the content in three months at 40℃. It is suggested that most of constituents are considerably stable when kept frozen.