Effects of Hydrazine on Electrophysiology, Behavior and Runway Performance in the Cat.

Abstract : The effects of intraperitoneally administered hydrazine on electrophysiology, general behavior and integrated performance in cats was evaluated in a number of independent studies. Doses of 15 to 20 mg/kg hydrazine resulted in death 2 to 24 hours after administration, preceded by overt emesis, salivation, panting and hyperactivity. Doses of 5 to 10 mg/kg produced emesis, hyperactivity and loss of appetite resulting in extensive weight loss. Exposure to 2 to 4 mg/kg produced lethargy and mild weight loss only. In runway performance tests, 1.5 mg/kg produced no significant alterations on the day of administration, but completely disrupted performance within 48 hours. A dose of 0.75 mg/kg hydrazine had no effects on the day of administration, but disrupted or altered performance were observed following a dose of 0.375 mg/kg hydrazine. Very low dose exposure to hydrazine can significantly alter performance capability without producing overt behavioral or physiological symptoms. (Author)