Theoretical Approach to Sustained-Release Multiple-Dose Therapy: Noncumulative Attainment of Desired Blood Level

Abstract Equations are presented to allow calculation of doses and dosing interval for multiple-dose therapy of sustained-release dosage forms.Both zero- and first-order release of drug from the dosage form are considered in developing these equations.Although special problems are associated with multiple dosing of sustained-release dosage forms because of their unique design, application of the appropriate equations yields relatively uniform blood levels of drug.