The RyR2-P2328S mutation downregulates Nav1.5 producing a ventricular arrhythmic substrate in murine ventricles.

This work was supported by Royal Society / National Science Foundation of China International Joint Project Grant (JP100994/ No.81211130599) (JAF and AM), Issac Newton Trust/ Wellcome Trust ISSF/ University of Cambridge Joint Research Grants Scheme (JAF) and by the Wellcome Trust and Medical Research Council (CLH).