UNFAVOURABLE PROGNOSIS MARKERS IN THE ASSOCIATION OF TYPE I SUGAR DIABETES WITH THE CELIAC DISEASE

The association of the celiac disease with sugar diabetes has been demonstrated by the common genetic aspect (HLA-DR3,) which correlates with the serious evolution of the type I diabetes. Object and method: During 2008-2009, we followed the quantification of the associated autoimmune phenomena through immunoenzymatic reactions on a group of 40 children with sugar diabetes of type I. Results: The immunologic markers' prevalence was: liver-kidney anti-microsomal antibodies 2.5%, soluble liver antigen 0%, glutamic acid anti-decarboxylase antibodies 35%, anti-tyrosine phosphatase antibodies 55%, anti-insulin antibodies 50%, cytoplasmic anti-insulin antibodies 2.5%, anti-thyroglobulin antibodies 11.1%, antithyroidperoxidase antibodies 23.1% and tissular antitransglutaminase antibodies IgA 25.7%. The main associations of the IgA tissular antitransglutaminase antibodies were with the glutamic acid anti-decarboxylase antibodies r=0.33 (p=0.027). Conclusion: Since the presence of the glutamic acid anti-decarboxylase antibodies was associated with the tissular antitransglutaminase antibodies IgA, these could be used as predictive markers in the unfavourable development of the type I sugar diabetes. Rezumat: Asocierea bolii celiace cu diabetul zaharat a fost demonstrată prin aspectul genetic comun (HLA- DR3), care se corelează cu evoluţia severă a diabetului de tip 1. Scop si metodă. Pe parcursul anului 2008- 2009 am urmărit cuantificarea fenomenelor autoimune asociate, prin reacţii imunoenzimatice, pe un lot de 40 copii cu diabet zaharat tip 1. Rezultate. Prevalenţa markerilor imunologici a fost: anticorpi antimicrozomi hepato-renali 2.5%, antigen solubil hepatic 0%, anticorpi antidecarboxilază acid glutamic 35%, anticorpi antitirozinfosfatază 55%, anticorpi antiinsulină 50%, anticorpi antiinsulari citoplasmatici 2.5%, anticorpi antitireoglobulină 11.1%, anticorpi antitiroidperoxidază 23.1% si anticorpi antitransglutaminază tisulară IgA 25.7%. Principalele asocieri ale anticorpilor antitransglutaminază tisulară IgA găsite au fost cu anticorpii antidecarboxilază acid glutamic r=0.33 (p=0.027). Concluzii. Deoarece prezenţa anticorpilor antidecarboxilază acid glutamic s-a asociat cu anticorpii antitransglutaminază tisulară IgA, aceastia ar putea servi ca marker predictiv in evoluţia nefavorabilă a diabetului zaharat tip 1.