Novel nicotinamide derivative

Object of the present invention is to provide an excellent inhibitory activity Syk- compounds and pharmaceutical compositions thereof. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein R1 represents a halogen atom; R2 represents each optionally having a C1-12 alkyl, C2-12 alkenyl group having at least one substituent, C2-12 alkynyl group, C3-8 cycloalkyl, aryl, -C1-6 alkyl, or heterocyclyl; each R3 represents an aryl group optionally having at least one substituent group or a heterocyclic group; and R4 and R5 are each independently It represents a hydrogen atom; and R2 and R4 may form a cyclic amino optionally having at least one substituent group) or a salt thereof with the nitrogen atom to which they are bonded together, and comprising a nicotinamide derivative or a salt thereof for related Syk the pharmaceutical compositions used in the treatment of disease.