Structure-sweetness Relationships of Aspartame derivatives by GUHA

Structure-Sweetness Relationships of Aspartame derivatives have been established using fingerprint descriptors by GUHA method. GUHA is the acronym for General Unary Hypotheses Automaton. The glucophoric hypotheses on the reasons for sweetness of aspartame derivatives were generated. Moreover, new results on sweetness receptor site topology have been found. The results were confirmed both by theoretical studies of other authors and chemical evidence. New knowledge obtained can be used for tailoring new aspartame analogous as artificial sweeteners.