The de Lange Syndrome

CONGENITAL disorders associated with failure of physical and mental development are common and their pathogenesis is seldom well understood. The finding of abnormal karyogram in certain congenital disorders has added a new dimension in our understanding of these syndromes and renewed the interest in others that have remained in obscurity for many years. The de Lange syndrome originally described in 1933 by Cornelia de Lange 1 was, until recently, only recognized in continental Europe. The number of reported cases has increased in 1963 mainly due to contributions from Great Britain and the United States. In the present paper, we shall report six additional cases of this syndrome.* Report of Cases Case1.—A white girl, the second child of healthy young parents (31 and 30 years old), was born four weeks before the estimated date of confinement. One sister of the patient was born four years before her, and a