Ferric Chloride: An Eco-friendly Catalyst for the Stereoselective Synthesis of 2-Deoxy Aryl-O-Rhamnosides

A facile and direct O -glycosylation method for the stereoselective synthesis of 2,6-dideoxy α- O -aryl-glycosides has been described using an eco-friendly catalyst, ferric chloride (FeCl 3 ). The approach can be applied to a wide range of differently substituted phenols including not only mono-substituted ones bearing electron-donating and electron-withdrawing groups but also disubstituted ones. Ultimately, 2,6-dideoxy aryl- O -glycosides were obtained rapidly (