Research progress on the relationship between plasma protein carbamylation and chronic kidney disease

Plasma protein carbamylation may change the structure of protein, thus influencing its function. Carbamylation is mainly through combination of cyanate with protein, which is elevated in patients with chronic kidney disease mainly because cyanate level is raised due to decomposition of the increasing urea in this population. Carbamylated plasma protein may influence the kidney directly, and has potential value in evaluation of complications, prognosis, and therapy of chronic kidney disease patients. This review introduced plasma protein carbamylation and summarized its value as a biomarker in chronic kidney disease, and promising therapy focusing on lowering plasma protein carbamylation based on recent advances. Key words: Chronic kidney disease; Plasma protein; Carbamylation