Industrial synthesis of a multi-stand imipenem

The present invention relates to a method for the preparation of carbapenem antibiotics multiply imipenem. The compounds of formula (I) compound dispersed in a solvent in a two-phase hydrogenation deprotection multiply layered to obtain imipenem enriched phase, the pH is adjusted with an acid to obtain crystalline imipenem multiply. PNZ: p-nitrobenzyl oxycarbonyl group benzyl; PNB: p-nitrobenzyl group.