Метилирование гена глутатион-S-трансферазы P1 (GSTP1) как диагностический маркер развития рака предстательной железы

During cancer development and progression, tumor cells undergo abnormal epigenetic modifications, including DNA methylation and histone deacetylation. These aberrations promote genomic instability and lead to silencing of tumor-suppressor genes; methylation status of some genes serves as the diagnostic marker for cancer. Somatic hypermethylation of CpG island sequences at GSTP1, the gene encoding the pi-class glutathione S-transferase, appears to be characteristic of human prostatic carcinogenesis. We present here a review of the literature describing the role of epigenetic alteration in cancer development and somatic GSTP1 changes in DNA from prostate cells and tissues.