Cerebroplacental ratio as predictor of adverse perinatal outcome in the third trimester.

INTRODUCTION Fetal growth restriction is associated with adverse perinatal outcome and the clinical management of these pregnancies is a challenge. The aim of this study was to investigate the potential of cerebroplacental ratio (CPR) to predict adverse perinatal outcome in high-risk pregnancies in the third trimester. Another aim was to study if the CPR has better predictive value than its components, middle cerebral artery (MCA) pulsatility index (PI) and umbilical artery (UA) PI. MATERIAL AND METHODS The study was a retrospective cohort study including 1573 singleton high risk-pregnancies with Doppler examinations performed at 32+0 to 40+6 gestational weeks at Lund University Hospital and the University Hospital of Malmo between December 29, 1994 and December 31, 2017. Receiver operating characteristics (ROC) curves were used to investigate the predictive value of the gestational age-specific z-scores for CPR, UA PI, and MCA PI, respectively, for the primary outcome "perinatal asphyxia/mortality" and the secondary outcomes "Birthweight small for gestational age (SGA)"and two composite outcomes: "Appropriate for gestational age/large for gestational age live-born infants with neonatal morbidity " and "SGA live-born infants with neonatal morbidity". RESULTS The performance in predicting perinatal asphyxia/mortality was poor for all three variables and did not differ significantly. The ROC area under curve (AUC) was 0.56, 0.55, and 0.53 for CPR, UA PI, and MCA PI z-scores, respectively. The ROC AUC for CPR z-scores to predict SGA was 0.73, significantly higher than that for both UA PI and MCA PI (p<0.001). The ability of CPR and the MCA PI to predict appropriate for gestational age/large for gestational age infant morbidity and SGA infant morbidity was similar and significantly better than UA PI (p<0.001). CONCLUSIONS In the present study none of the three Doppler measures proved to be useful in predicting perinatal asphyxia and mortality. CPR and MCA PI were equally good in predicting neonatal morbidity, especially in SGA pregnancies, and both were significantly better predictors than the UA PI. CPR had a high predictive value for SGA at birth, better than that of its two components, UA PI and MCA PI.