Effects of polysaccharide sulfate on the contents of monoamine neurotransmitters in the cerebral tissue of ischemia-reperfusion injury rat

Aim:To observe the effects of polysaccharide sulfate (PSS)on the contents of monoamine neurotransmitters in the cerebral cortex and striatum tissue of cerebral ischemia-reperfusion injury rats.Methods: Sixty rats were randomly and equally allocated into sham operation group, model group, high-,mediun- and low- dose PSS groups, and nimodipine group.Except for sham operation group, the other five groups were estabished ischemia-reperfusion model using the suture emboli method.The contents of 5-HT,NE,and DA in the cerebral cortex and striatum tissue of each group were determined by fluorospectrophotometry. Another 60 rats were grouped and treated as above, and the neural function were evaluated.Results:Compared with sham operation group, the neural function of model group were worse,and the contents of 5-HT,NE,and DA decreased significantly. Compared with model group, neural function were improved, and the contents of 5-HT,NE,and DA in PSS groups and nimodipine group increased significantly (P0.05).Conclusion: The protective effects of PSS on the ischemia-reperfusion injury rats were related to the improvement of disturbance of monoamine neurotransmitter metabolism.