Transition-metal-free catalytic hydroboration reduction of amides to amines
2020
The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation. Here, we present a combined KOtBu/BEt3 catalyst for the deoxygenative reduction of tertiary, secondary, and even notoriously challenging primary carboxamides with pinacolborane (HBpin) at 25–60 °C. This novel transition-metal-free methodology is readily applicable to the synthesis of drug molecules.
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